Volatile odors in our environment bind specific sensors in the nose, called odorant receptors (ORs). Even though the full OR repertoire was identified in 1991, only 10% of all human ORs have a known ligand. The fundamental reason why large-scale odor-profiling of ORs has been lagging, is that ORs are notoriously hard to express outside their native environment (i.e., in vitro). Hence, conventional pharmacological screening methods cannot be used to identify which odors bind with what receptors. MouSensor, LLC uses mice (our so-called MouSensors) as bioreactors to express large amounts of fully functional human ORs in their native environment, i.e., an olfactory sensory neuron (OSN).  Our revolutionary platform technology allows us to easily customize different MouSensor lines and to build an entire library of animals covering the full human OR repertoire.  We are currently translating our in vivo technology to an ex vivo odor detection platform to build a human-nose-on-a-chip, which integrates the MouSensor biology with state-of-the-art chip technology. Our biological nose-on-a chip has tremendous potential in Flavor and Fragrance R&D, explosive detection and even in disease diagnostics and biomarker discovery.