At MouSensor, LLC we believe that the sense of smell is widely undervalued and that improved knowledge of the olfactory system will lead to breakthrough technologies. Unlike any other sense we have no vocabulary to describe how something smells. Not only is olfaction instrumental to our enjoyment of taste, smells also alert us of dangers, such as fires, poisonous fumes and spoiled food. The olfactory sense is extraordinarily sensitive and has an enormous impact on our mood and emotions.
By combining our extensive expertise in the science of olfaction with cutting-edge biotechnology we have created a versatile genetic biosensor tool to provide assistance to humans in important scent detection tasks, such as fragrance-smell pharmacology, noxious-smell pharmacology, non-invasive disease diagnostics, explosives detection and isolation of novel odorants. Our revolutionary platform can cover the entire human odorant detection potential and will transform the application of this enigmatic sense.
Founded and headquartered in New York City, we are proud to be part of a vibrant biotech entrepreneurial ecosystem which allows us to attract talented graduates and experts to achieve our scientific goals.
Volatile odors in our environment bind specific proteins, called odorant receptors (ORs), in the nose. Even though all ORs are known, only 10% of all human ORs have a known ligand. The fundamental reason why the functional characterization of ORs has been lagging since the identification of the OR gene repertoire in 1991 is that ORs are notoriously hard to express outside their regular biological context; conventional in vitro pharmacological methods cannot be used to study the biology of olfaction. Therefore, OR coding has to be studied in a whole, living organism, such as the mouse. However, the study of OR coding in vivo is hampered by the low representation (0.1%) of any given OR.
Using our patented MouSensor technology we can dramatically increase the representation of any (mouse or human) odorant receptor in the nose of a mouse. Our revolutionary platform technology allows us to create a library of MouSensors covering the entire human odorant detection potential paving the way for high-throughput Smell Pharmacology.